| Title: |
Studies on the Chemical Nature of the Substance [12 of 23] |
| Alternative Title: |
Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III |
| Creator: |
Avery, Oswald T. |
| Contributor: |
MacLeod, Colin M. |
| Publisher: |
Journal of Experimental Medicine |
| Date: |
1944-01-00 |
| Subject: |
Cellular signal transduction
|
| Description: |
From the Journal of Experimental Medicine Vol. 79, No. 1. |
| Type: |
Text |
| Format: |
text/plain |
| Language: |
en |
| Identifier: |
avery-pg12.jpg |
| Source: |
Master scanned with Epson GT-10000+ flatbed scanner at 600 dpi. |
| Rights: |
http://osulibrary.orst.edu/specialcollections/coll/pauling/dna/copyright.html |
| Full Text: |
148ÂRANSFORMATION OF PNEUMOCOCCAL TYPES A highly viscous solution of the nucleate in distilled water in a concentration of
1 mg. per cc. was used. 1.0 cc. amounts of heated and unheated sera diluted in saline as shown in the preceding protocol were
mixed in Ostwald viscosimeters with 4.0 cc. " Dilution of the digest mixture of serum and transforming substance. of the
aqueous solution of the nucleate. Determinations of viscosity were made immediately and at intervals over a period of 24 hours
during incubation at 37°C. The results of this experiment are graphically presented in Chart 1.¢n the case of unheated serum
of both dog and rabbit, the viscosity fell to that of water in 5 to 7 hours.og serum heated at 60°C. for 30 minutes brought
about
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