- LP journal entry in diary entitled "France and England 1952 also Toronto" RE: "V.N. Orekowitch 'Sur la synthise du procollagene.'
Should get x-ray patterns of x line procollagen." Borsook interprets his experiments having to do with amino acids incorporation
and protein
molecules.
- "T.S. Work. Extract cells killed rapidly during rapid growth, and fractionated. Lysine also, and valine. Mammary gland is
magnificent factory for manufacture of proteins. R- glycine infected (C14)
More in milk than in plasma protein, therefore plasma protein not precursor of milk protein. Newberger, using Xline Hb, and
labeled valve, found no difference in incorporation."
- "Work says Horowitz in his book pointed out that many negative results could be explained by assumption that protein molecules
are synthesized in tots from our acids. Horrowitz says he means about
10000 nMW synthesized at once."
- "Research. Give theoretical discussion of CH3, CH2, etc.- configuration, force constants, entropy, etc. For CH3 [draws a molecule with three Hs] With about 10% H+ C- character the bond strength
difference of sp3 and sp2 may be overcome, giving planar molecule- but easily deformed out of plane. Also discuss NH2 radical. I calculate {2 bond drawings} W=Q+d, hence resonance energy
neutralizes repulsion. I suggest (bond energy)- (bond energy for 0.18 larger distance) = heat of activation. Use Badper's
rule?"
- "Work suggests that in a animal species all protein have a common polypeptide structure. He says immunological proportions
of same protein from different animals are different, of different proteins
of same species rather similar. I would have said the opposite. [Monod?] also said he found some [immunol.?] proportions for
same enzyme in different species. He suggested a speculative mechanism
(not clear)about adaptive enzymes. I think [degredn ?] is rarely stepwise, and peptides are hardly distinguishable from the same."
- "Dr. Weber, Tubingen, says that he will invite me to Germany next Spring- Unitarian auspices-"
- "Dr. Marle Julia 112 rue Cordine Cardinet"
- "RH Hall MS Geo. Wright, PhD Todd next spring. Did [nitroguanidine?] work with [GW?]. NCB Include section on structure of
same radicals. Perhaps on structure of activated complexes. Also my
old work on excited states. Benson rays CA; July or Aug 1952, mentions Russian discovery of H2O4" [includes drawing of H2O4 molecule].
- [scrap paper folded and enclosed in journal] RE: "cyclization can occur only between 2 and 3." [drawing of molecular configuration].
"Deoxyribo is HCH at C2." [molecular configurations drawn below
having to do with cytosine and ribonuclease].
- "AA Albanese says on lysine-deficient diet plasm proteins go from 5.2 to 7.0% arganine! (Infants, human) Even to 8.2% (Wheat
gluten diet, which is deficient in lysine)"
- "Hanrowitz says Porter in Cambridge has investigated first five amino acids in rabbit gamma-globulin (normal) and anti-ovalbumin
and found them the same. Iodoovalbumin concentrates in
mitochondria of liver cells (Hanrowitz) Also (Hanrowitz) C14 labeled azoprotein- after 5 months still 1000 or so molecules per mitochondria! Hence antigens stay in cells for long times.
Beef serum glob
and S come only (S= sulfonic acid benzine) stays in blood of rabbit about 1 or 2 days and then is taken out into Kupffer cells
and mitochondria, when some antibody is made. With many S (20 or 30) the
injected stuff is taken into cells at once- few minutes."
- "Heidelberger [graph drawn of Antibody cirvulating vs. time "against polysacch." and "against protein antigen"]
- Ab against polysacch stays high- 50% of max- for 8 months or more. No enzymes in body to hydrolyze these polysaccharides."
- "Wurmser Bloods of types A.O. and OO have different B-agglutinins, MW about 500000 and 170000 resp."
- "Dr. Chase (?) Rocks. Zust. Enzyme in bacterium. Mutation lethal above 25 degrees not below. Enzyme in mutant denatures at
25 degrees. Has same Michaelis constant as [p-word?] Molecular disease.
Perhaps it is Hodgkins."
- "See Werner Mass Cold Spring Harbor 1951. May be same or different. Norm Hanrowitz has a molecular disease of tyrosinase."
- "Dr. Thomas L Gresham Res Dir of B F Goodrich has Beta-propiolactone (pure) that he would provide us. Dr. Mangan (Ford Hosp.)
says it is radiomimetic, like mustard, and he is studying its effect on
virus (hepatitis) He discovered this. He said that diacetyl ethylene has a specific action on a certain meningitis virus,
in serum."
- "Philip Hennily Official gov. lab.
- Gen. Desmaronx trans. N. ch. Bond now retired.
- M. Luzzati Discussed translation, correction of errors. Gave him copy of Gen Chem.
- Henily- NaOH . 4H2O done
- 7H2O Pattersons done.
- Luzzati HNO3 . 3H2O [drawing of N, O, H molecular configuration including numerical notes]
- Another H2O is [draws another configuration]
- also gives stronger (shorter) H bonds when accepting proton, weaker when donating.
- Other H2O is tetrahedral."
- "Magat uses dephenylpicrylhydrazyl (use due to Barlett- refer to him)
- free radical from colored to colorless. It is a stable free radical [molecular configuration drawing] (probably steric). Magat
uses it to assay free radicals formed by radiation."
- "Donzelot was Pres. of U. of Nancy, now Director of higher Ed. Physical Chem.
- Magat says at conference on physical chem this spring a meeting (Jeff Wymiar present) on salaries of scientists."
- [mapped out comparison of salaries between scientific professions and between several countries]
- "AHP read Valence Enc Brit. and gave advice. Linoleic and arachadonic acids (one or other) required. They give essential fatty
acids. Burr and - about 1920.
- Letter from Henry Allen Moe, Guggenheim Memorial Foundation, to LP RE: Answering LP's question found in a 7-15-52 letter, It is doubtful whether Dr. Donohue's grant could be raised above its current $4500.00. [Filed under LP Science: 14.010].
- LP Newspaper Clippings: 1952n. Article in unknown newpaper titled "Best Interests" discusses LP's passport problems and reports
that LP has finally been given a restrictive passport to France and England.
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