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|"Men and Molecules: Molecular Medicine" February 26, 1962.
Produced by the American Chemical Society
Drawing the Analogy between Antibodies and the Sickle Cell Anemia Process. (0:57)
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Linus Pauling: Making an analogy with antibodies, we might say that perhaps these patients manufacture an abnormal sort of hemoglobin molecule
that is capable of combining with itself; that has a region on one side that just fits neatly onto the region on the other
side of a similar molecule. The molecules of hemoglobin would clamp onto one another, the second one onto the first one, the
third one onto the second, and so on, forming a long rod. This long rod would line up with similar rods; general forces of
attraction would bring them together, forming a long, needle-like crystal of hemoglobin, which as it grew in the red cell,
would finally become longer than the diameter of the cell. Then as it continued to grow it would twist the red cell out of
shape into the elongated forms that are observed.
ClipCreator: Linus Pauling
Clip ID: 1962v.2-antibodies
Full WorkCreator: American Chemical Society
Associated: Linus Pauling
Date: February 26, 1962
Copyright: More Information